Skin Regeneration, Repair, and Reconstruction

Skin Regeneration, Repair, and Reconstruction

Skin has important functions in several life-preserving processes such as hydration, protection against chemicals and pathogens, and heat regulation. Severe damage to the skin may therefore be life-threatening. Skin regeneration and wound healing require an orchestrated integration of complex biological and molecular events, which include inflammation, proliferation, and remodeling. Despite the...

Repair and Regeneration.

Wound repair and regeneration.

The skin is the biggest organ of the human being and has many functions. Therefore, the healing of a skin wound displays an extraordinary mechanism of cascading cellular functions which is unique in nature. As healing and regeneration processes take place in all parts of the human body, this review focuses on the healing processes of the skin and highlights the classical wound healing phases. W...

Stem cells and skin regeneration.

Stem cells represent a great hope for regenerative medicine. In adult life, stem cell deposits are kept in organ niches; the need for tissue or organ regeneration mobilizes stem cells via the SDF-1-CXCR4 regulation axis. Constant regeneration of the skin is achieved due to stem cell differentiation within the epidermis and the hair follicle; thus, skin may serve as an excellent source of stem c...

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair.

Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here, we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had ...